Synthesis and structural analogs of novel Schiff bases derived from sulfadoxine with 4-acetyl/benzoyl-1-(4’-nitrophenyl)-3-methyl-2-pyrazolin-5 one their metal complexes and antibacterial a

A. S. Thakar, H. B. Friedrich,

Abstract

4-acetyl/benzoyl-1-(4’-nitrophenyl)-3-methyl-2-pyrazolin-5-ones condensed with sulfadoxine to form Schiff bases. These Schiff bases form complexes type of ML2.2H2O (M= Mn, Fe, Co, Ni, Cu). Elemental analysis, magnetic susceptibility, electrical conductance, electronic and infrared spectral data suggested octahedral structures for the complexes. All the compounds were tested for their antibacterial activity. The results indicate that the growth of the tested organism was inhibited by most of the compounds. These Schiff bases were characterized by elemental analysis, mass spectra, 1H NMR, 13C NMR and FT IR spectra.