Synthesis and spectrochemical study of some Albendazole derivatives

J. El harti*, M. Ansar, A. Ben

Abstract

The Albendazole is the drug of reference in the medical treatment of hydatidosis, but its efficacy is limited by its poor bioavailability. Two series of ester and amide potential prodrugs of albendazole (1a-d and 2a-f) were synthesized. Other set of the new benzimidazole derivatives as alkyl derivatives were synthesized from the albendazole 3a-j. The compounds thus prepared were characterized by their physical (TLC) and spectral data (IR and NMR).