Research Article
Srinivas Bethi, Matta Vidyasag
Abstract
Benzimidazole, a physiologically active nucleus, has attracted the attention of many researchers from the point of its chemistry and biological activity. A good number of them have been also marked as drugs, albendazole (antihelmintic), carbenadazim (fungicide), emedastine (antihistamine), omeprazole (proton pump inhibitor), Droperidol and pimozide ( psychopharmacological agent), etc. The schematic protocol is fusing the moieties of benzimidazole and thiazolidinones and synthesizing novel 3-[1H-benzimidazole-2-yl-amino]-2- phenyl-1,3-thiazolidin-4-one, such five compounds are synthesized and characterized by its physical data like Molecular formula, Melting point (°C), Molecular weight & Yield %. The spectral analysis is carried for the synthesized compounds by IR and Mass spectrum. These structures with screening them for possible CNS activity like gross behavioral studies and locomotion activity