Synthesis and pharmacological activity of 2-(2-substituted-phenyl)-3-(4-{1-[2- (1H-tetrazol-5-yl)-biphenyl-4-ylmethyl])-1H-benzoimidazol-2-yl}-phenyl)- thiazolidin-4-ones

M. C. Sharma a, D. V. Kohli a,

Abstract

An easy and efficient method to obtain Schiff bases of [2-(2-substituted-phenyl)-3-(4-{1-[2-(1Htetrazol- 5-yl)-biphenyl-4-ylmethyl])-1H benzoimidazol-2-yl}-phenyl)- thiazolidin-4-one] using different aromatic aldehydes. Reaction mixture of Schiff base (0.01 mol) and mercaptoacetic acid (0.05 mol) dissolved in dioxane (50 ml), anhydrous zinc chloride (0.008 mol) was added and refluxed for 12 hrs. The reaction mixture was cooled, filtered, washed with 10 % w/v sodium bicarbonate solution. After reactions with compounds sodium azide (1.50 g, 13.43 mmol), and Et3N·HCl (4.2 g, 16.31 mmol) in NH4Cl (30 mL) is stirred at 40◦C for 8 hours [A-O]. The compounds obtained were identified by spectral data and were subjected to a prediction of biological activities. All synthesis compounds screened for Angiotension (A II) Receptor Antagonist antihypertensive activity with biphenyl tetrazole Schiff bases Thiazoldine-4-one shows good activity compared with losartan