Synthesis and in vitro antitumor activity of new benzothiazole and benzoxazole derivatives

Manal M. Kandeel, Eman K. A. A

Abstract

A series of benzothiazole and benzoxazole derivatives were synthesized from their parents whom bearing oaminocyano groups then functionalized on amino group or cyano group. Some of the newly formed compounds were evaluated, in vitro, for their antitumor activity against MCF-7. Compound 4b was the most potent, showing activity IC50 (0.011 μM ).