Research Article
*D. Kumudha, R. R. Reddy, T. K
Abstract
A series of substituted aryl thiazolidin-4-ones (4a1-a9 - 4e1-e9) were synthesized by the reaction of substituted schiff’s bases (3a1-a9 – 3e1-e9) with thioglycolic acid in presence of ethanol. The schiff’s bases (3a1-a9 - 3e1-e9) were inturn obtained by the condensation of substituted benzohydrazides (2a-e) with substituted aryl aldehydes in ethanol and the substituted benzohydrazides were prepared by condensing benzoyl chlorides (1a-e) with hydrazine hydrate in methnol. The structures of the synthesized compounds were characterized by FT-IR, 1H-NMR spectral analysis. Some of the synthesized compounds were screened for their anti-inflammatory, analgesic activities and the biological results revealed that in general substituted aryl thiazolidin-4-ones afforded good protection against inflammation and pain. All the test compounds exhibited significant anti-inflammatory and analgesic activities.