Synthesis and evaluating cardiac effects of 3,4-dihydropyrimidin-2-one-5-carboxylates in isolated atria of animal model

Moein Rashidifar, Mohsen Imens

Abstract

The synthesis and cardiac activity of four 3,4-dihydropyrimidin-2-one-5 carboxylates are reported. We synthesized 3,4-Dihydropyrimidinones (DHPMs) by Biginelli reaction using classic and microwave methods and the yield of these methods compared with each other. Then cardiotonic activity of four derivatives of DHPMs was investigated on isolated perfused right atria. Compound 2b had significant chronotropic effect in comparison to negative control at concentration of 0.01M.