Synthesis and characterization of some new 3, 5-disubstituted pyrazoline and isoxazoline derivatives

Nilesh R. Thakare and Amol K.

Abstract

Base catalyzed condensation of 4–chloroacetanilide (1) with different aromatic aldehyde (2a-c) gives N-(4- chlorophenyl)-3-(4-substitutedphenyl)-acryl amide (3a-c). These acryl amides(3a-c) on treatment with hydrazine hydrate and hydroxylamine hydrochloride in the presence of ethanol/glacial acetic gives 3, 5-disubstituted pyrazolines (4a-c) and 3, 5-disubstituted isoxazoline (5a-c) respectively. 1-Benzoyl-3, 5 disubstituted pyrazolines (6a-c) has been synthesized by the treatment of (4a-c) with benzoyl chloride in pyridine. All the newly synthesized compounds were characterized by analytical and spectral studies.