Original Articles
Vamangi M Pandya and Sachin A
Abstract
Polyoxometalates (POMs) are inorganic metal–oxygen group anions class of compounds. They are distinctive in its topological and electronic adaptability and are significant in numerous disciplines. POMs are proved to be important for applications in medicine and in material science. An accumulative number of possible uses for POMs in human medicine are vividly described in the several recent literatures. Here, we represent nano-composite formation of tungsten containing anticancer polyanion, K6H[CoW11O39(CpTi)].13H2O (CoW11CpTi) with biocompatible ChitosanYC-100 (CSYC100). This synthesis was attained without the aid of any cross-linker through electrostatic interaction technique. This title anion CoW11CpTi is reported to be the most potent anti-cancer POM amongst the family of CpTi substituted POMs studied so far. This POM-chitosan nano-composite was characterized using Fourier Transform Infrared Spectroscopy (FTIR); dynamic light scattering (DLS), Transmission Electron Microscopy (TEM) and Thermo Gravimetric Analysis (TGA). The release profile recorded was slow and sustained at physiological pH. Cytotoxicity assays which shows an attribute to reduce the toxicity of these POM were performed on C2C12 (mouse myoblast cell line) and A-549 (lung cancer cell line), which proved the reduced toxicity of nano-composites as compared to the bare drugs. Thus, this study has designated the probability of using POM-chitosan nano-composite for less toxic and effective biomedicinal applications.