Synthesis and biological activity of some new thiazole based thiazolidinones

V. G. Patel, Tulsigiri K. Gosw

Abstract

The basic compound 5-methyl-N-[(1-substituted phenyl) methylene] – 1,3-thiazol-2-amine [A 1-10] have been synthesized by reaction of 5-methyl amino thiazole and aromatic aldehyde in presence of toluene and further react with thioglycolic acid gives 3-(5-Subtituted 1,3-thiazol-2-yl)-2- (Substitued phenyl)-1, 3-thiazolidin-4-ones [B 1-10]. The structure of the final product is confirmed by IR, and 1H NMR spectral data. All the synthesized compounds were evaluated for their antibacterial activity to gram-positive and gram-negative bacteria. All the synthesized compounds have exhibited selective and effective active against gram-positive and gram-negative bacteria. Antibacterial activities of the synthesized compounds have been compared with standard drugs