Research Article
Arun Singh, Deepak Kumar and F
Abstract
2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetohydrazide (3) undergoes facile condensation with aromatic aldehydes to afford the corresponding 2-(5-benzoyl-1H-benzo[d]imidazol-1-yl)-N'- alkylidene aceto hydrazide (4a-h) in good yields. Cyclocondensation of compounds (4a-h) with thioglycolic acid yields 3-(2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetyl)-2-alkylthiazolidin-4- one (5a-h). These (5a-h) compounds are for the reacted with benzaldehyde in the presence of sodium ethanolate affords, giving 3-(2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetyl)-5- benzylidene-2-alkylthiazolidin-4-one (6a-h). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.