Synthesis and antimicrobial screening of some thiazolidine derivatives of isoniazid

Research Article

Rakesh Patel and Anil Bhandari

Abstract

Some new N-(4-oxo-2-alkyl/aryl-thiazolidine-3-3yl) isonicotinamide derivatives of isoniazid have been synthesized and evaluated for their Anti-bacterial, Antifungal and Anti-tubercular activity. Synthesized compounds show significant activity against bacterial, fungal and mycobacterium strains. Their structures were established on the basis of elemental analysis, IR, 1H NMR and Mass Spectral data.

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