Synthesis and antimicrobial elucidation of [1,2,4]-triazole-3-thione derivatives

D. R. Godhani, D. B. Sanja and

Abstract

4-Methyl benzoyl isothiocyanate 2 is prepared by a reaction of 4-methyl benzoyl chloride I and ammonium isothiocyanate. Compound 2 reacts with phenyl hydrazine in the presence of acetone to form 1-phenyl-5-p-tolyl-1,2- dihydro-[1,2,4]triazole-3-thione 3. Compounds 3 on reaction with formaldehyde and different aromatic amines in 1,4-dioxane yielded 2-(substituted-amino)methyl-5-(p-tolyl)-1-phenyl-1H-1,2,4-triazole-3(2H)-thione 4a-j respectively. The synthesized compounds 4a-j were screened for their antibacterial and antifungal activities and were characterized by spectroscopic techniques like IR & NMR.