Research Article
Chandrashekhar C. H.1, Latha K
Abstract
A series of 2-amino-4-(phenylsubstituted)-6-naphtho[2,1-b]furan-2-ylnicotinonitrile derivatives 4(a-g) have been prepared by the cyclocondensation of malononitrile, aromatic aldehyde and ammonium acetate with 2-acetylnaphtho[2,1-b]furan. The similar reaction of 4(a-g) with alcoholic KOH and phenylisothiocyanates resulted in the formation of various 2-amino-6-(1,2-dihydronaphtho[2,1-b]furan-2-yl)-4-phenylsubstitutedpyridine-3- carboxamides 5(a-g) and 6-{[-3-(phenylsubstituted)-1-( naphtho[2,1-b]furan-2-yl)but-2-en-1-ylidene]amino}-4- imino-3-phenyl-3,4-dihydro pyrimidine-2(1H)-thione derivatives 6(a-g) respectively. The structures of the newly synthesized compounds have been established on the basis of analytical and spectral data. The synthesized compounds have been screened for antimicrobial activity