Research Article
Anju Goyal and Sandeep Jain
Abstract
A series of 1-phenyl-3-(4-(3-propanoloxy) phenyl)-5-aryl-1H-pyrazoles were synthesized from chalcones i.e., 3-aryl- 1-(4-hydroxyphenyl) prop-2-en-1-ones and studied for their in vitro antibacterial activity. Chalcones 1 on reaction with phenyl hydrazine yielded the corresponding 1-phenyl-3-(4-hydroxyphenyl)-5-aryl-1H-pyrazoles 2 which on further reaction with 3-chloropropanol furnished the title compounds 3. These compounds were characterized by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and their minimum inhibitory concentration (MIC) were determined