Research Article
Rizwan A. Sheikh, Ashish Turas
Abstract
To evaluate the notropic activity of alcoholic extract of flower of Securinega leucopyrus (AEFSL) using Interoceptive Behaviour model in mice. Nootropic activity of the AEFSL was evaluated using Interoceptive Behaviour models (Diazepam and scopolamine induced amnesia) in mice, Standard drug like Piracetam was used as reference in each model. Preliminary phytochemical studies with AEFSL revealed the presence of phytoconstituents like glycosides and flavonoids in the extract. When this extract is subjected for LD50 studies, produced abnormal behaviour or mortality even at the dose level of 2000 mg/Kg body weight in mice. Three different doses like low 1/20th (100 mg/Kg), medium 1/10th (200 mg/Kg) and high 1/5th (400 mg/Kg) doses from the maximum dose tested for LD50 were selected for the present study. Piracetam and AEFSL treated groups when compared to Diazepam and scopolamine induced amnesic mice the increased inflexion ratio were observed. The present study on notropic activity with AEFSL confirmed the above mentioned effect because of several phytoconstituents like flavonoids as these were already reported for their nootropic activity.