Study of the accelerated stability of amoxicillin made in DR Congo

C. Kalonji Mubengayi, Y. Ramli

Abstract

The objective of this work was to study the accelerated stability of amoxicillin 500mg sold on the Congolese market. Four specialties of Amoxicillin were examined: three locally manufactured generics and the originator. Two analytical tests were made to study the change during the storage: The dosage of active ingredient by HPLC and dissolution profile by UV / Visible spectrophotometer. The results of this study reveal a problem with the manufacturing processes of Congolese generics. That is caused because they all present an abnormal drop of active ingredient and a release below the limit, from the third month of storage at a temperature and relative humidity of 40 °C and 75%.