Study of novel pyrrolidine compounds

Gunvantsinh T. Desai, D. K. Gu

Abstract

4-(1,3-dioxoisoindolin-2-yl)benzohydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding N'-arylidene-4-(1,3-dioxoisoindolin-2-yl)benzohydrazide (2a-e) in good yields. Compounds (2a-e) on cyclo condensation with Succinic anhydride yields 1-(4-(1,3-dioxoisoindolin-2-yl)benzamido)-5-oxo-2- arylpyrrolidine -3-carboxylic acid (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities