Research Article
Paresh N. Patel and Hasmukh S.
Abstract
In this study, 3'-(4-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl)phenyl)spiro[indoline- 3,2'-thiazolidine]-2,4'-dione 5 was synthesized by facile and fast procedure, which further underwent condensation with glucose and p-chlorobenzaldehyde to afford 6 and 7, respectively. Compound 7 was used as precursor for the preparation of some fused heterocyclic compounds 8-11. Among them, compound 8 was alkylated using chloroacetic acid and dichloroacetone to afford 12 and 13, respectively. Also, it reacted with acrylonitrile and hydrazine hydrate to afford 14 and 15, respectively. Compound 12 was condensed with p-chlorobenzaldehyde and glucose to afford 16 and 17, respectively. Selected members of the synthesized compounds were screened for antimicrobial activity.