Studies in the Presences of BF3·OEt2 Catalysts of Some Benzimidazole Derivatives [2-(substituted-phenyl)-6-methoxy-1-[2'-(1H-tetrazol-5-yl)- biphenyl-4-ylmethyl]-1H-benzimidazole] with Potent antihyp

M. C. Sharma a, D. V. Kohli a,

Abstract

Series of substituted benzimidazole derivatives [2-(substituted-phenyl)-6-methoxy-1-[2'-(1Htetrazol- 5-yl)-biphenyl-4-ylmethyl]-1H benzimidazole] good yields from 4-methoxy-1, 2- phenylenediamine and different substituted carboxylic acids in the presence of BF3·OEt2 as a catalyst with biphenyl tetrazole.Synthesis compounds have been evaluated for antihypertensive activity direct and indirect methods and confirmed by IR,1H NMR,MS and elemental analysis