Stability evaluation of lipid nanocapsules in parenteral nutritional mixture

Y. Rahali, Y. El Alaoui and Y.

Abstract

Olive and soybean oils are commonly used in parenteral nutrition. Lipid NanoCapsules based on vegetal oils (vo-LNC) can be used to allow both an easy dispersion of the oily phases in water and an improvement of parenteral mixture stability. To evaluate the stability of vo-LNC by size measurement, we chose to inspire us from the storage conditions and measurement intervals of the guideline of international conference on harmonization (ICH); stability testing of new drug substances and products Q1A(R2). Results showed that the size of vo-LNC was stable which allows safe administration by parenteral use.

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