Original Articles
Waqar Ahmed, Tahseen Ahmed, Ar
Abstract
Worldwide, it was noticed that various brands are available for metformin with number of drug delivery system- same brands are also available and marketed in Nawabshah. The main theme of this study is to evaluate 05 different brands of metformin tablets marketed in nawab shah city for physico-chemical evaluation, various officials and un-official test were performed including weight variation, friability hardness, content uniformity and dissolution. All available brands of metformin come under official specification for friability and weight variation. The result indicates that 02 brands Met 02 & Met 05 passed the hardness test while Met 01, Met 03, Met 03 & Met 04 brands were failed for hardness, test, As for as content uniformity was concern Met 02, Met 03 and Met 05 satisfied the official results as mentioned in USP (United States Pharmacopeia). While met 01 and met 04 did not show the specified result, met 02, met 04 and met 05 brands released 70-80% of their drug content within 30 min except met 01 & met 04, which did not pass the acceptance criteria as mentioned in USP.