Original Articles
Akmal D.*,Netty Suharti, Syafr
Abstract
The formulation of microcapsule of 2.4-dichlorophenoxy acetic acid [(2,4-D)] using a biopolymer of polycaprolacton as matrix by solvent evaporation method has been carried out. In the study, three types of the microcapsule formulation was used with the ratio between 2.4-dichlorophenoxy acetic acid, and polycaprolactone, (PCL) of 2:1, 1:1, and 1:2 respectively. The particle distribution was measured using a calibrated microscope. Active substance release was determined by UV-Vis spectrophotometer. Results indicated that biopolymer of polycaprolactone can be used as the matrix polymer for slow release preparations and influence the release of active substance of 2.4-D in the objects. It is also observed that the recovery test of active compound of 2,4-D of formula 2 was of 86.5% w/w. This value was higher than Formula 1 (84.175%w/w) and formula 3 (78.2% w/w). The kinetic model of active compound released from microcapsules with corelation coefficient of near by 1 and followed the zero order kinetic obtained from formula 1.