Short communication
Oluwatobi S Oluwafemi
Abstract
The optical analyses showed an enhancement in the fluorescent intensity after the functionalization with improved optical properties. The functionalized NPs (F-NPs) displayed higher cell viability compared to the bare NPs when investigated on KM-Luc/GFP cell line at different concentrations. The fluorescent image indicated that the as-synthesized functionalized NPs were taken up by the cells. Recommendations are made for treatment centers to become trauma- informed that would help this recognition. Semiconductor core shell nanostructures have generated a lot of interest in various areas such as optics, electronics, and bio-medical applications due to their tunable chemical and physical properties across the visible spectrum. These properties are highly dependent on the size, shape and the composition of nanomaterial. The composition of NPs plays a critical role in the stability, toxicity and solubility of the nanomaterial in biologicaluid. Fur-the more, studies have shown that apart from composition, sur-face functionalization of QDs plays an important role in the endocytosis process and has been reported to further reduce cyto-toxicity. Thus, functionalization and cytotoxicity assessment of nanomaterials have been an exciting research direction in bioimaging applications. We have previously reported on the cytotoxicity as well as stability of thiol-stabilised CdTe and CdTe/CdSe core-shell QDs. The results showed that the shell in-creased the stability but the cell viability against the mouse-bioclast histiocytoma cells was very poor. In this communication, we improve the stability as well as the cell viability of the as synthesised CdTe/CdSe QDs by growing ZnSe shell to producemulti-core-shell structure. Furthermore, by functionalizing the surface of the assynthesised CdTe/CdSe/ZnSe core- multi shellQDs with amino-acid, the cell viability was significantly enhanced. This makes the assynthesised core-multi-shell QDs a good candidate for optical imaging and drug delivery applications. The synthesis was carried according to our reported method with slight modifications. The molar ratio of Cd/Te/MPA/NaBH4 wasxed at 1:0.2:1:10. After 5 mins of reaction, the solution was reduced at 98C.