Sickle Cell Disease Clinical Trials and Phenotypes

Chinedu A Ezekekwu, Taiwo R Ko

Abstract

More recent evidence however suggests the likelihood of four independent mutations of the sickle cell gene in different populations; three of which occurred in Africa. The trans-Atlantic slave trade accounted for the gene movement from Africa to the Caribbean and United States of America and lately migration has resulted in the introduction of the gene to the United Kingdom and other parts of Europe. The incidence of SCD in England (1:200 births) is increasing and the high prevalence is due to the high percentage of births to mothers of West African origin.