Schiff base complexes derived from thiosemicarbazone, synthesis characterization and their biological activity

Ruchi Agarwal, Mohd. Asif Khan

Abstract

The Schiff bases anisaldehyde thiosemicarbazone (ATC), 3-4, dimethoxy benzaldehyde thiosemicarbazone (DMBTC), thiophene-2 aldehyde thiosemicarbazone (TATC), 2-acetyl pyridine thiosemicarbazone (APTC) and acetyl acetone thiosemicarbazone (AATC) were prepared by standard methods and characterized by M.P. & I.R. Spectra. Their complexes with palladium {(Pd ATC), (Pd DMBTC), (Pd TATC), (Pd APTC), (Pd AATC)} ruthenium {(Ru ATC), (Ru DMBTC), Ru (TATC), (Ru APTC), (Ru AATC)} and rhodium {(Rh ATC), (Rh DMBTC), (Rh TATC, (Rh TATC), (Rh APTC), (Rh AATC)} have been prepared by standard method and characterized by elemental analyses, electrical conductance, magnetic susceptibility, IR and electronic spectral studies molar conductance. Both the ligands and their complexes have been screened for their fungicidal & bactericidal activities and the results indicate that they exhibit significant antimicrobial properties.