Role of Nanocarriers for Enhancement of Drug Bioavailability

Ankush Kumar Sharma, Deepa Neg

Abstract

There is constantly increasing demand of nanocarriers systems in the field of nanotechnology from the last two decades. The nanocarriers systems are widely used in the delivery of biotech drugs for the improvement of bioavailability and target delivery. Nanocarrier systems provide several advantages over the conventional formulations. This review describes an approach which encapsulates drug compounds within biodegradable and biocompatible nanocarriers such as Nanosuspensions, Polymeric, Lipid and Inorganic Nanocarriers along with their advantages and role in drug delivery. Development of new drug delivery systems always remains a challenging approach in the field of biotechnology that targets the drug to a specific site and provides the desired therapeutic effect at the required time. Due to low solubility, poor membrane permeability, or extensive pre-systemic metabolism, the drug compounds are not suitable for the conventional oral formulations. This article presents an overview of various types of nanocarriers including the method of Nanoparticles preparation. The problems arises in the drug delivery can be overcome by use of pharmaceutical nanocarrier systems.

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