Meenakshi Gothwal
Abstract
Cervical cancer is the most common cancer in India. Screening of cervical cancer helps in marked reduction in invasive cervical cancers. The low sensitivity of Papanicolaou cytology(Pap smear) and high risk human papillomavirus( HR-HPV) in excluding High grade intraepithelial lesion (ASC-H) leads to unnecessary referrals to colposcopy guided biopsy. The combined cervical cytology screening and HR-HPV has its own limitations and still need further standardization. Using additional biomarkers like dual staining with p16 and Ki-67 might help in triaging abnormal pap smear. The aim of our study is to know the dual immunostaining for p16/Ki-67 in predicting the presence of significant lesion in cases of mild cytological atypia.