Role of Animal Models in the Study of Human Genetic Polycystic Kidney Disease

Yiqiang Cai

Abstract

Study on animal models plays important role in understanding the molecular basis underlying the human genetic diseases. Dozens of animal models for human polycystic kidney disease (PKD) have been established and provided insightful information in better understanding of PKD in either pre-genomic or post-genomic time. Here we highlight studies of genetic animal models for PKD that brought novel insights on understanding the pathogenesis of PKD