Retrospective Review of 374 Samples, Circulating DNA; As a Biomarker Assay to Support Clinical Management in Solid Tumors Treated with Multi Targeted Epigenetic Therapy (MTET)

Nezami M, Klowsowski C an

Abstract

Our current understanding of cancer biology and epigenetic science has transformed our ability to provide therapies more precisely to genetic and epigenetic targets causing tumor growth and disrupting its behavior. In concert with our efforts to regulate the transcription of altered genes involved in tumor biology, we have focused on a range of epigenetically regulated motor genes that control key molecular targets of the tumor, involved in its growth and metastases. Statistical analysis of the targets determined by epigenesis showed an improvement in the results compared to the historical control.

Relevant Publications in Journal of Biological and Medical Sciences