Research Article
Jadhav A. S*, Tarkase K. N. an
Abstract
Metoprolol succinate is a selective β1 receptor blocker drug used in hypertension and other cardiac diseases. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed a new, precise and simple UV spectrophotometric methods for estimation of Metoprolol Succinate from bulk and tablet formulation in phosphate buffer 6.8. The drug obeyed the Beer’s law with correlation coefficient 0.9999 and 0.9979 respectively for Method I and Method II. It showed absorption maxima at 223 nm and 226 nm respectively for method I and Method II; in phosphate buffer 6.8. The linearity was observed between 5 – 25 μg/mL. The results of analysis were validated by recovery studies, accuracy, precision, LOD, LOQ and ruggedness. The method was found to be simple, accurate, precise, economical and robust.