Quantitative determination of amoxicillin trihydrate in medical forms using kinetic method

Karpova Svetlana P

Abstract

The kinetic of conjugated reactions of S-oxidation and perhydrolysis of amoxicillin with potassium hydrogenperoxomonosulfate in alkaline medium is studied by the increase of forming product light absorbance at 296 nm. The procedure of the quantitative analysis of amoxicillin in capsules, pills and suspension by spectrophotometric-kinetic method is elaborated using triple potassium Caro’s salt solution («ÃƒÆ’Âžxone») as a reagent. RSD ≤ 2.00 %. The obtained results have good agreement with the Pharmacopoeia one δ = (+0.1…–1.3) %.