Research Article
Prasanna Datar
Abstract
A compound 2-(anilino)-1-(4-phenylphenyl)ethanone was synthesized by reaction between biphenyl acid chloride and aniline. The synthesized compound was screened for analgesic activity. The selection of the compound was on the basis of QSAR study performed on the biphenyl analogs having anti-inflammatory activity. 2D QSAR study using topological descriptors revealed the important features required for the design of new potent anti-inflammatory agent. QSAR equation found in present study had r2 of 0.842 and internal predictivity of 0.69. Using QSAR results a molecule was designed to have analgesic activity.