Pyridoxal Phosphate a Possible Intervention to Prevent Aminoglycoside Induced Electrolyte Imbalance

Afzal H. Asif , Sahibzada T

Abstract

Aminoglycosides are very effective against most Gram negative infections, but nephrotoxicity and electrolyte imbalance caused by these compounds pose problems in patients where electrolyte balance needs to be watched closely. The electrolyte imbalance contributes to derangement of the renal functions. This issue has been addressed by changing the dosing schedule and supplementing the patients with these electrolytes. However electrolyte administration and adjusting aminoglycoside doses have their own demerits. In our present study we investigated the effects of Pyridoxal phosphate on electrolyte balance when given in combination with aminoglycosides. Our findings suggest that Pyridoxal phosphate prevents aminoglycoside induced electrolyte imbalance, a finding which has not been reported previously. These results should be considered as an important input regarding prevention of aminoglycoside induced decrease in electrolyte levels. Further studies will help healthcare providers to manage patients more efficiently, in whom electrolytes balance may need to be observed.\r\n