Research Article
Dr. Ratnesh Namdeo Gajbhiye, D
Abstract
Objective: Present study was undertaken to find out the pulmonary function test in type II diabetics. Background: Diabetes is a disease which affects multiple organ systems. Major consequence of hyperglycemia is excessive non enzymatic glycosylation of various body proteins including haemoglobin, albumin, collagen and elastin. Due to this, there occur irreversible changes in the chemical structure of tissue proteins. Basement membrane and connective tissues in skin, muscles, respiratory system, vascular bed, kidney, peripheral nervous system, etc. are the targets for glycosylation. Diabetic patients show reduced pulmonary function tests. Method: 42 Type II diabetics and 40 normal subjects were selected for the study. Anthropometric parameters, blood investigations and P.F.T. were performed on all subjects. Result and Discussion: Anthropometric parameters like Weight, B.M.I., and B.S.A. were found to be non significant in Type II diabetics. Fasting and Post Meal blood glucose levels as well as HbA1c % were significantly more in Type II diabetics as compared to controls. All P.F.T. parameters excepting FEV1 % were also significantly less in Type II diabetics. Decreased P.F.T. in Type II diabetics can be attributed to increased glycosylation of connective tissues and other proteins in the lungs, leading to a decrease in elasticity, flexibility and recoiling capacity ultimately producing stiff lung i.e. restrictive lung pathology.