Production of Fibrinolytic Enzyme by Streptmyces Rimosus at Conditions of Nitrogen Limitation

Victoria Gesheva

Abstract

The kinetic of the enzyme production of Streptomyces rimosus, a producer of exoproteases was investigated in conditions of nitrogen limitation.The maxima of fibrinolytic and caseinolytic activities by Streptomyces rimosus were reached at 84 h, respectively 96 h. Values of activities were increased 5-fold with those on initial medium. The ultrastructure changes were followed. In the earlier hours an aggregation of ribosomes in cells was established. Large membranes and numerous electron- transparent structures were found. The obtained results indicated close connection between cell status of the producer, its enzyme productivity and an ability of the strain to survive at conditions of nitrogen limitation.