Original Articles
Jamal Ali Ashoor, Qasim Allawi
Abstract
Solubility is an important physiochemical element that affects the absorption and effectiveness of desired drug. Failure in formulation development of the drug has been considered as the consequences of its poor aqueous solubility. The reduced solubility of and low dissolution rate in aqueous gastrointestinal tract most often lead to inadequate bioavailability of the drug. In the present study the solubility and dissolution rate of finasteride which show poor solubility has been developed by solid dispersion(SD) technique with different polymers such as polyethylene glycol 6000 (PEG6000) and Hydroxypropyl Methyl Cellulose (HPMC). SD of finasteride (FNS) was prepared by using 60,120 and 200 mg of the polymer for 200 mg of the pure FNS in each formula using solvent evaporation method. Formula containing 200mg of HPMC showed best release rather than other formulas.