Original Articles
Fatimah Mohammed Hussein Wais,
Abstract
Ketoprofen is class II type drug according to (Biopharmaceutics Classification System BCS) with low solubility and high permeability. The effective surface area of drug particle is increased by a reduction in the particle size. Since dissolution takes place at the surface of the solute, the larger the surface area, the further rapid is the rate of drug dissolution. The aim of this investigation was to increase the solubility and hence the dissolution rate by the preparation of ketoprofen nanoparticles using solvent evaporation method. Materials like PVP K30, poloxamer 188, HPMC E5, HPMC E15 and HPMC E50 were used as stabilizers in perpetration of different formulas of Ketoprofen nanoparticless. These formulas were evaluated for particle size, effect concentration of drug and effect of injection volume ratio. All of the prepared Ketoprofen nanosuspensions formulas showed a particle size result within Nano range. The average particle size of Ketoprofen nanosuspensions formulas was observed from 31.2 nm to 676.5 nm. SEM images for Ketoprofen nanoparticle showed a reduction in an average particle size compared to pure powder and DSC DSC illustrated that the crystallinity of Ketoprofen was partially lost in lyophilized powder and converted to an amorphous form. The results indicate the suitability of solvent evaporation method for Ketoprofen with improved in vitro dissolution rate and thus perhaps enhance fast onset of action for drug.