Original Articles
Padmadevi Chellapa,Ahmad Musta
Abstract
VCO Emulsions were prepared using high-speed stirrer with various surfactant concentrations and mixing ratio. The resultant mixture was added with distilled water. Among the formulation, best optimum formulation was selected for secondary homogenization using High Pressure Homogenizer (HPH) to produce of VCO Nanoemulsion in the range 20-200nm. The secondary homogenization process involves using variable parameter of pressure and homogenization cycle number. According to the results the VCO Nanoemulsion consists of 20% of VCO, 5% surfactant and 75% distilled water. 5% of the optimum VCO Nanoemulsion formulations with the smallest droplet size 153nm and Poly Dispersed Index (PDI) value of 0.139 were selected to incorporate with a 0.5% hydrogel concentration and distilled water mixed to produce VCO Nanoemulgel. Based on the characterization of VCO Nanoemulgel with droplet size of 163nm and 0.211 PDI value, low viscosity and pH value of 5.6-6.0 were suitable for topical usage and accelerated stability study indicates that VCO Nanoemulgel is a stable formulation.