Post-surgical Colorectal Cancer (CRC) surveillance: PET/CT versus CT

Mazarieb Mai

Abstract

Introduction:  Forty percent of CRC patients will fail, mostly within first two years following primary resection. Early detection of recurrent disease has been reported to improve their survival. The use of PET/CT during the follow-up process is equivocally superior to contrast enhanced CT. This study is a comparison of CT vs. PET/CT. Methods: Medical records of all patients who had R0 radical colorectal surgery for Stage 1-3 disease between 1.2000 and 1.2016 were retrospectively reviewed. All patient who experienced recurrence and had both abdominal and/or chest CT scans followed by PET/CT within 60 days, were included in the study. A radiologist reviewed all images for disease recurrence. Findings consistent with recurrent disease were compared between the two modalities. Results: Of 35 CT images 14 identified lung nodules; 10 of these 14 were confirmed malignant by FDG uptake. .9 CT images identified liver lesions, all were called “cystic”; PET/CT identified 10 liver cases; 6 of these 10 cases were called disease recurrence to the liver. One case was not demonstrated by CT while PET/CT did identify a disease recurrence in the liver. CT and PET/ CT both identified 7 peritoneal cases, but only 3 cases; were FDG avid (see table). PET/CT identified all anastomotic recurrences (N=4), these were noted only 3 times on CT. Conclusions: A notable proportion of patients with negative findings on routine CT performed presented with a positive PET/CT. PET/CT should be employed in the follow-up protocol and replaced the CT. Biography: Mai Mazarieb is a MD at Department of General Surgery, Rabin Medical Center, Zarzir, Israel. Her study focused on entitled post-surgical Colorectal Cancer (CRC) surveillance: PET/CT versus CT. Her research interest focus on cancer, surgery. Speaker Publications: “Melanoma Seeding at the Chest-Wall Port Site Following the Thoracoscopic Removal of a Right Lower Lobe Metastasis”, Annals of Surgical Case Reports, Volume 3, Issue 1, Article 1026, Published: 17 Feb, 2020 Outaggarts Z, Johnstone S, Goodman A. Port-site metastasis after laparoscopic surgery with rapid second recurrence in early stage endometrial carcinoma: A case report and review of the literature. Open J Obstet Gynecol. 2015;5(6):324-32 Emoto S, Ishigami H, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, et al. Port-site metastasis after laparoscopic surgery for gastrointestinal cancer. Surg Today. 2017;47(3):280-3. 17th International Conference on Cancer; Barcelona, Spain - June 15-16, 2020.    Abstract Citation: Mazarieb Mai, Post-surgical Colorectal Cancer (CRC) surveillance: PET/CT versus CT, Cancer Research 2020, 17th International Conference on Cancer; Barcelona, Spain - June 15-16, 2020. (https://cancer-research.cancersummit.org/abstract/2020/post-surgical-colorectal-cancer-crc-surveillance-pet-ct-versus-ct)