Phytosome: Phytoconstituent based lipid derived drug delivery system

Shyam Baboo Prasad, Sonam Bhat

Abstract

Polyphenolic plant secondary metabolite have antioxidant, anti-inflammatory, anti cancer, antiobesity and hepatoprotective properties but owing to their polar nature they have poor absorption which ultimately lead to their poor systemic bioavailability, thereby their therapeutic efficacy gets reduced. Phytosome: a phytoconstituent based lipid derived drug delivery system can surpass these drawbacks .phytosomes are phospholipid-substrate complex in which there occurs the formation of weak hydrogen bonds between the polar portion while the non polar tail of phospholipid wraps over the complex thereby imparting lipophilic character to it and hence increases its absorption.