Pharmacokinetics study and efficacy evaluation of Ceftriaxone and Tazobactam combination in ESBL E. coli infected diarrhoeic poultry birds

Madhusudana Rao

Abstract

 The infections caused by ESBL strains of E. coli were often related to diarrhea in poultry birds. The present research work was undertaken to study the pharmacokinetic profile of Ceftriaxone and Tazobactam in healthy and ESBL E. Coli infected with diarrheal birds (broiler, Rhode Island red, Haringhata black) after a single intramuscular administration of the combination Ceftriaxone Tazobactam (8: 1) at 28.125 mg kg-1. The efficacy of the Ceftriaxone Tazobactam combination has been evaluated for ESBL-producing E. coli infection in birds (Broiler, Rhode Island Red, Haringhata Black) at a predetermined dosing schedule supported by a pharmacokinetic study. For induction of infection in experimental broiler, Rhode Island Red and Haringhata Black birds, 56 × 108 CFU / ml of the bacterial culture was orally inoculated. Broiler chickens developed severe diarrhea on the 7th day after oral inoculation of 1 ml of E. ESBL-producing coli, while moderate diarrhea occurred in Rhode Island Red birds on the same day.