Pharmacokinetic properties, docking study and anti-cancer evaluation of s-triazine-cytosine hybrids

M. Karthicka, C. M. Mahalakshm

Abstract

A series of cytosine substituted s-triazinyl derivatives (C1T, C2T &C3T) were synthesized. Pharmacokinetic parameters such as absorption, distribution, metabolism, excretion of these hybrids were determined by in silico method. Docking studies have been performed with their catabolic enzyme. The viability of HepG2 liver cancer cells and normal hepatocyte in the presence of these hybrids were assessed by MTT assay. The IC50 values of these compounds showed less viability exhibited in tumor cells compare to normal cells. The hybrid molecules distinguish between cancer cell from normal cell and reducing the toxicity.