Oral Glucose Tolerance Tests with Aerial Parts of Abroma augusta L. (Sterculiaceae)

Mohammad Omar Farque, Mahmudul

Abstract

Oral glucose tolerance tests were carried out with methanolic extract of Abroma augusta aerial parts (leaves and stems) in glucose-loaded mice. The extract at doses of 50, 100, 200 and 400 mg per kg body weight dose-dependently and significantly reduced blood glucose levels in hyperglycemic mice by 40.2, 40.7, 41.9, and 45.4%, respectively. A standard antihyperglycemic drug, glibenclamide, when administered to hyperglycemic mice at a dose of 10 mg per kg reduced blood glucose level by 41.9%. Thus the studies reveal that the extract possess considerable antihyperglycemic activity and can possibly be used to lower high blood glucose levels present in disorders like diabetes.