Optimization of production procedures for coenzyme Q10 from Rhodobacter sphaeroides

Juan Wang1, Xin Nie2, Li Zhang

Abstract

In the present study, single factors including inoculate amounts, fermentation temperature, fermentation duration, ratio of fermentation media volume to total flask volume were optimized for enhancing the production of coenzyme Q10 from Rhodobacter sphaeroides. The experimental results suggested that optimal single factor was: inoculate amounts 2%, fermentation temperature 30 ºC, fermentation duration 72 h, fermentation media volume to total flask volume 60%. The production of CoQ10 was 28.22 mg/L, enhanced by 141.6% compared to the conditions before optimization. The present study will promote the large scale production of CoQ10 from microorganisms.