Optimization of Direct Compression’s Co-Processed Excpient Mannitol- Polyethylene Glicol (PEG) 6000 in Manufacture of Vitamin C Tablets

A Mumtihanah Mursyid, Saleh Wi

Abstract

Tablet excipients for direct compression should have a good flowability and compactibility. Mannitol commonly used as tablet diluents is less hygroscopicity, brittle and poor flowability and compactibility. The aim of this research was to improve the flowability and compactibility of mannitol by co-processing mannitol-PEG 6000 fabricated by wet milling technique. Optimum co-processed Mannitol-PEG 6000 were used in manufacture of vitamin C tablets. The co-processed material obtained were evaluated; particle size distribution, average diameter, density, porosity, flowability, compactibility, SEM, PXRD and DTA. Optimum co-processed Mannitol-PEG 6000 generates tablets of vitamin C model drug that meet the USP requirements of tablet dosage, which include hardness, friability, disintegration time and dissolution test. The flowability of co-processed mannitol-PEG was increased in the range of 6.92±0.64 to 6.91±0.74 g/second and the tensile strength of co-processed mannitol-PEG was increased which were 2.77±0.07 Mpa was higher than its physical mixture 2.15±0.07 MPa. X-ray diffraction analysis result of co-processed had similiar pattern with mannitol. SEM the tablet made by co-processing technique was more compact. In manufacture vitamin C tablets showed that formulation vitamin C by co-processed mannitol-PEG was great tablet. The co-processed mannitol-PEG is more promising to use as direct compression material.