One-pot three-component synthesis of new oxindoles through a tandem etherification-coupling sequence ignited by tungstophosphoric acid

Chengyuan Liang, Zhishu Tang,

Abstract

A facile approach was developed to assemble brand new oxindoles 4 and 12 via a three-component condensation of isatin 1, alcohol 2 and symmetrical dione (2,4-pentanedione 3 or cyclohexanedione 11 ). The oxindoles are formed in excellent yields (56-89%) in the presence of tungstophosphoric acid as an efficient recyclable catalyst within a short period. The revealed synthetic protocol and the novelty of the corresponding oxindoles will largely assist our drug discovery and development program.