Original Articles
Masumeh Abdoli-Senejani, Molud
Abstract
The three component condensation of an aldehyde, ï¢-dicarbonyl and urea (or thiourea) using barium chloride in the presence of nitric acid has been investigated. The 3,4-dihydropyrimidin-2(1H)-one derivatives were synthesized in high yields at short reaction times. Barium chloride is one of the useful and inexpensive catalysts that can be easily separated and are not contaminated by products. The activity of the recycled BaCl2 was examined and it was seen that the catalyst displayed very good reusability. This method offers several advantages including high yields, environmental friendliness, short reaction times, cheapness of catalyst, simple work up procedure and easy isolation, which make it a useful process for synthesis of dihydropyrimidones as well as the thio derivatives.