Novel first derivative UV spectrophotometric method for the determination of celecoxib in solid dosage forms

Santosh R. Karajgi*, Ramaling

Abstract

A simple, precise, rapid and economical procedure has been developed for estimation of Celecoxib in bulk drug and pharmaceutical solid dosage form. In this study UV- spectrophotometer Shimadzu model UV 1800 was used. The first order derivative spectrophotometric method was employed for estimation of Celecoxib using analytical grade methanol as solvent. Celecoxib has absorbance at λmax 252nm. Celecoxib obeys Beer’s law in concentration range 5-30μg/ml and the recovery studies verified accuracy of the purposed method; result validated as per ICH guideline and results were found satisfactory and reproducible. The method was successfully performed for the estimation of Celecoxib in capsule dosage form without the interference of common excipients.