Research Article
SanaVenkata Lakshmi Reddy, Kon
Abstract
A series of new N-substituted sulfonamides, 9-(substituted phenylsulfonyl)-4-(oxiran-2-ylmethoxy)-9H-carbazole 6(a-d) and carbamates, substituted phenyl/aliphatic-4-(oxiran-2-ylmethoxy)-9H-carbazole-9-carboxylate8(a-f) were synthesized in high yields through simple straight forward reaction of 4-(oxiran-2-ylmethoxy)-9H-carbazole (3) with various substituted sulfonyl chlorides and chloroformates in the presence of sodium hydride as a base. The structures of the synthesized compounds were confirmed by IR, NMR (1H, 13C), mass and elemental analysis data. All the compounds were screenedin vitroantibacterial (Staphylococcus aureus, Bacillus subtilis and Escherichia coli), antifungal (Fusariumoxysporum, Candida albicans and Aspergillusniger) activities and antioxidant activities using DPPH and NO methods. All the compounds exhibited moderate to potent antimicrobial activities and good antioxidant activities.